This course is designed to cultivate analytical skills in students as they assess patients’ conditions and utilize clinical data to formulate differential diagnoses and treatment plans. Through collaborative group work, students will engage in comprehensive case studies, progressing from diagnosis to therapy and anticipated outcomes. The curriculum consists of a series of small-group case exercises, facilitating the integration of knowledge across dermatology, otolaryngology, ophthalmology, cardiology, pulmonology, and nephrology. This approach ensures that students not only develop critical thinking skills, but also apply their learning in a practical context. As a longitudinal course, it runs concurrently with the system courses throughout the second, third, and fourth semesters of the program.